My vet suggests I use it twice weekly instead of what the label suggests. I have b vitamin deficiencies and I don't want the doggies to have it too. This size bottle is not available everywhere thought it does not come with the dropper so you might want to buy the smaller bottle first or use a dropper you have on hand. I give one full dropper full twice a week on food. The dogs (between 63 & 83# each) don't know the difference!